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This house, like all of the houses on Lowell Road with the exception of the pre-development 8-10 and 12-14 Lowell, was built by Maurice Dunlavy and designed by Royal Barry Wills.

22 Lowell Road was the home of Francis C. (1889-1965) and Margaret W. Rogerson (1895-1991) and their family, who were listed at this address in the Street List from 1929 to 1940. Francis Rogerson was a banker. His father, Charles, was president of the Boston Safe Deposit and Trust Company. Francis' brother Henry lived at 37 Lowell. The Rogersons had a son, Francis Jr.

The 1930 U.S. Census listed the residents as: Francis C. Rogerson, 40, trust officer (bank); Margaret W. Rogerson, 34; Francis C. Rogerson, 1; and Christine McCharles (?), 38, maid, born Canada.

Listed next at this address, in 1941 and 1942, were Albert and Florence Cerf and Alice Bloomberg, all previously at 1223 Beacon Street, and Leo and Esther Gordon, previously in Brighton. Esther and Florence were probably sisters and most likely daughters or nieces of Alice Bloomberg. Albert Cerf was listed as a broker; Leo Gordon was listed as a salesman; and Esther Gordon was listed as a chemist one year and a technician the next.

Edith R. and Samuel J. Katz were the next residents, listed her from 1943 until the late 1960s. Samuel was listed variously as a salesman, convertor, manufacturer, and executive in the 1940s.